Marijuana Messes up Memory, Painkiller Prevents Problem

In an article of LiveScience neuroscientists David Robbe and Gyorgy Buzsaki at Rutgers University and their colleagues recorded hippocampus activity (linked to memory activity) in rats. Normally brain cells in this region often synchronize their electrical activity. When they injected rats with THC, they found the normally synchronized workings of the hippocampus became disrupted. While the cells did not change how often they fired nerve impulses, their timing became erratic. This inconsistent firing of the nerve impulses results in disorientation, causing memory and learning difficulties.

A new study suggests that pain relievers found in many medicine cabinets may help prevent some of these learning and memory problems, especially useful to medicinal smokers who wish to keep their head clear.

Researchers found that mice treated with THC had an increase in levels of a chemical called cyclooxygenase-2 (COX-2) in the hippocampus. Ibuprofane and Celebrex are painkillers which lower the COX-2 level, and so these findings suggest that giving people a COX-2 inhibitor drug along with medical marijuana may help to problems linked with its long-term treatment.

Moreover, marijuana helps counterfeit the side-effects of painkillers such as gastrointestinal inflammation because the endocannabinoid catabolic enzymes protect against gastropathy.

The gathered data indicates that the phytocannabinoid Δ(9)-THC protects against diclofenac-induced gastric inflammatory tissue damage.

Further testing is still needed in human clinical trials. At this point, it's still too early to determine the dose or frequency of Celebrex or ibuprofen, but it's surely interesting...